Induction of Superficial Bladder Tumors in the Female Fischer 344 Rats with Ay-27 Tumor Cells for the Study of Dd7fusion and Localization of Hemoglobin Derived Components (Hematoporphyrin Derivative) In Vhcw of Photochemotherapy
| Autor: | Jean-Francis Bisson, Francis Guillemin, Pierre Labrude, C. Vigneron, Dominique Notter |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Hematoporphyrin
Pathology medicine.medical_specialty Biodistribution Bladder cancer Urinary bladder business.industry Skin photosensitivity medicine.medical_treatment Biomedical Engineering Photodynamic therapy medicine.disease chemistry.chemical_compound medicine.anatomical_structure chemistry In vivo medicine Photosensitizer business Biotechnology |
| Zdroj: | Artificial Cells, Blood Substitutes, and Biotechnology. 27:77-84 |
| ISSN: | 1532-4184 1073-1199 |
| DOI: | 10.3109/10731199909117485 |
| Popis: | Photochemotherapy (PCT) consists in administration of a photosensitizer and subsequent irradiation of the tumor with visible light. Routinely, the photosensitizer is given intravenously (i.v), but the major drawback of this procedure is the resulting skin photosensitivity. The goal of our study is to examine whether intravesical (i.b.) instillation of the photosensitizer for PDT of bladder cancer might be feasible in order to target the tumors and to avoid the photosensitization phenomenon.After first studying the biodistribution of hematoporphyrin derivative (HpD) in vivo in the rat bladder, two and four hours after intravesical administration, by fluorescence microscopy, we compared two different methods for the induction of superficial bladder tumors in rats with AY-27 tumor cell line in order to perform the same study on bladder tumors.The best results for the penetration depth of HpD in the normal bladder wall were obtained two hours after the bladder instillation where the photosensitizer was detect... |
| Databáze: | OpenAIRE |
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