Autor: M. O. Lozinskii, V. V. Shelyakin, Alexander N. Chernega
Rok vydání: 2002
Předmět:
Zdroj: Russian Journal of Organic Chemistry. 38:1661-1665
ISSN: 1070-4280
DOI: 10.1023/a:1022522420258
Popis: By condensation of 2-(2-thenoyl)-1-cyclohexanone with cyanothioacetamide a new compound of aseries of chalcogen-containing isoquinolines with a thiophene fragment in its structure was prepared. It wasdemonstrated that alkylation of the compound with haloalkanes, their derivatives, in particular with thosehaving electron-withdrawing substituents furnished 3-alkylthio-4-cyano-5,6,7,8-tetrahydroisoquinolines.Some of the latter underwent cyclization into 3-amino-2-R-5-(2-thienyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline.
Databáze: OpenAIRE