Popis: |
By condensation of 2-(2-thenoyl)-1-cyclohexanone with cyanothioacetamide a new compound of aseries of chalcogen-containing isoquinolines with a thiophene fragment in its structure was prepared. It wasdemonstrated that alkylation of the compound with haloalkanes, their derivatives, in particular with thosehaving electron-withdrawing substituents furnished 3-alkylthio-4-cyano-5,6,7,8-tetrahydroisoquinolines.Some of the latter underwent cyclization into 3-amino-2-R-5-(2-thienyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline. |