Does C60 fullerene act as a transporter of small aromatic molecules?
| Autor: | Leonid A. Bulavin, Yuriy Prylutskyy, Oleksandr I. Ivankov, Agnieszka Borowik, Grzegorz Gołuński, Uwe Ritter, Łukasz Kawelski, O. A. Kyzyma, Dariusz Wyrzykowski, Anna Woziwodzka, Jacek Piosik, V. V. Cherepanov, Rajmund Kaźmierkiewicz, Maxim P. Evstigneev |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Fullerene Biomolecule Isothermal titration calorimetry 02 engineering and technology Surfaces and Interfaces General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Membrane Dynamic light scattering chemistry Drug delivery Acridine Molecule Physical and Theoretical Chemistry 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 164:134-143 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2018.01.026 |
| Popis: | C60 fullerene is reported to directly interact with biomolecules, such as aromatic mutagens or anticancer drugs. Therefore, it is extensively studied for its potential application in the fields of drug delivery and chemoprevention. Understanding the nature of fullerene-drugs interactions might contribute to optimization and modification of the existing chemotherapy systems. Possible interactions between ICR-191, a model acridine mutagen, with well-established biophysical properties and mutagenic activity, and C60 fullerene aqueous solution were investigated by broad range of biophysical methods, such as Dynamic Light Scattering, Isothermal Titration Calorimetry, and Atomic Force Microscopy. Additionally, to determine biological activity of ICR-191-C60 fullerene mixtures, Ames mutagenicity test was employed. It was demonstrated that C60 fullerene interacts non-covalently with ICR-191 and has strong affinity to bacterial membranes. The obtained results provide practical insight into C60 fullerene interactions with aromatic compounds. |
| Databáze: | OpenAIRE |
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