Dermal cysts participate in reparative regeneration of epidermis in Hr hr /Hr hr mice

Autor:	P. K. Golovatenko-Abramov, E. S. Platonov, V. S. Bocharova, E. G. Kolokolchikova, E. A. Zhirkova
Rok vydání:	2010
Předmět:	Pathology medicine.medical_specialty integumentary system Skin wound Regeneration (biology) Mutant Anatomy Degeneration (medical) Biology medicine.anatomical_structure Dermis Skin surface medicine Epidermis Developmental biology Developmental Biology
Zdroj:	Russian Journal of Developmental Biology. 41:240-246
ISSN:	1608-3326 1062-3604
Popis:	One of the phenotypic effects of mutation in the Hr gene in mice is disintegration of hair follicles and their degeneration into open funnel-shaped structures (utricles) opened on skin surface and cysts located in the depth of the dermis. The aim of the current study consists in analysis of the process of reparative regeneration of skin in homozygotous mice with one of the mutant alleles of the Hr gene—Hrhr. It is shown that epithelial cells that constitute the inner pavement of cysts take part in the process of epithelization of deep skin wounds. This indicates that the competence of ectodermal cells in relation to inductive signals from injured skin remains in Hrhr homozygote mice, in spite of the significant anatomic abnormalities of the hair follicles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d684474c5f8b855ddebf30ac677faaf5 https://doi.org/10.1134/s1062360410040041 Zobrazit plný text záznamu Full text from SpringerLink