Sex Differences in Contractile Function in Cardiac Hypertrophy and Heart Failure Subsequent to Volume Overload
| Autor: | Paramjit S. Tappia, Mohamad K. Nusier, Anureet K. Shah, Naranjan S. Dhalla |
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| Rok vydání: | 2020 |
| Předmět: |
Pressure overload
medicine.medical_specialty education.field_of_study Heart disease business.industry Population Volume overload medicine.disease Muscle hypertrophy Heart failure Internal medicine cardiovascular system Cardiology Medicine Myocardial infarction business education Ventricular remodeling |
| Zdroj: | Sex Differences in Heart Disease ISBN: 9783030586768 |
| Popis: | Cardiac hypertrophy is an adaptive response of the heart to hemodynamic overload that is initially designed to maintain cardiac functioning, but prolonged hypertrophy becomes detrimental and results in cardiac dysfunction and heart failure (HF). Population studies have indicated that men and women are different in their risk and etiology in developing HF. In fact, female sex hormones are believed to have a cardioprotective role during premenopause. Although cardiac remodeling in experimental volume overload has also been shown to occur in males, there is still a paucity of information regarding sex differences in the pattern of ventricular remodeling and contractile function in response to volume overload. Therefore, this article discusses the sex differences in changes of ventricular dimensions and contractile function in cardiac hypertrophy and HF due to volume overload. Furthermore, it describes cardiomyocyte Ca2+-handling properties that could potentially contribute to sex differences in cardiac remodeling and contractile function. The influence of sex hormones that are present during these processes is also highlighted. Since sex differences in the development of cardiac hypertrophy have been reported to occur in pressure overload and myocardial infarction, some of these changes are also described for a comparative perspective. Understanding the sex differences in the pathophysiology of heart disease may form the foundations for the development of new approaches for sex-specific treatment and prevention of HF. |
| Databáze: | OpenAIRE |
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