A perspective on C. elegans neurodevelopment: from early visionaries to a booming neuroscience research
| Autor: | Georgia Rapti |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ved/biology ved/biology.organism_classification_rank.species Perspective (graphical) Cell lineage Biology Genome Cell function 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Genetics Connectome Neuroscience research Model organism Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurogenetics. 34:259-272 |
| ISSN: | 1563-5260 0167-7063 |
| DOI: | 10.1080/01677063.2020.1837799 |
| Popis: | The formation of the nervous system and its striking complexity is a remarkable feat of development. C. elegans served as a unique model to dissect the molecular events in neurodevelopment, from its early visionaries to the current booming neuroscience community. Soon after being introduced as a model, C. elegans was mapped at the level of genes, cells, and synapses, providing the first metazoan with a complete cell lineage, sequenced genome, and connectome. Here, I summarize mechanisms underlying C. elegans neurodevelopment, from the generation and diversification of neural components to their navigation and connectivity. I point out recent noteworthy findings in the fields of glia biology, sex dimorphism and plasticity in neurodevelopment, highlighting how current research connects back to the pioneering studies by Brenner, Sulston and colleagues. Multifaceted investigations in model organisms, connecting genes to cell function and behavior, expand our mechanistic understanding of neurodevelopment while allowing us to formulate emerging questions for future discoveries. |
| Databáze: | OpenAIRE |
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