A Prognostic Model of the Development of Cognitive Impairments in Patients with Type 1 Diabetes Mellitus
| Autor: | M A Rotkank, N. G. Zhukova, I. V. Tolmachev, Dmitry Kudlay, Yu. G. Samoilova, M. V. Matveeva |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Type 1 diabetes business.industry General Neuroscience Cognition medicine.disease Proton magnetic resonance Clinical Practice 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine Prognostic model medicine In patient Neuropsychological testing Cognitive impairment business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and Behavioral Physiology. 50:1136-1139 |
| ISSN: | 1573-899X 0097-0549 |
| Popis: | Objective. TO develop a prognostic model of the development of cognitive impairments in patients with type 1 diabetes mellitus using proton magnetic resonance spectroscopy data. Materials and methods. The study included patients with type 1 diabetes mellitus (DM) and people without DM (control group). Carbohydrate metabolism was assessed in all participants, and all underwent neuropsychological testing (using the MoCA test) and proton magnetic resonance spectroscopy of the brain. Results were analyzed statistically in IBM SPSS Statistics 20.0. The prognostic model was computed by discriminant analysis. Results. Proton magnetic resonance spectroscopy data and discriminant analysis yielded a prognostic model for the development of cognitive impairments in patients with type 1 diabetes mellitus. Conclusions. The method developed here for the early diagnosis of cognitive impairments provides early prognostication of the development of cognitive impairments in patients with type 1 diabetes mellitus and can be used in clinical practice to assess the efficacy of treatment used for the prophylaxis of cognitive impairment. |
| Databáze: | OpenAIRE |
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