| Autor: |
Quan-Jian Lv, Zhi-Wei Ma, Xiao-Feng Liu, Xiao-Pei Chen, Chuan-Chuan Wang, Jing-Chao Tao |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Letters in Organic Chemistry. 19:908-912 |
| ISSN: |
1570-1786 |
| DOI: |
10.2174/1570178619666220128142038 |
| Popis: |
Abstract: A new tertiary amine-thiourea organocatalyst has successfully been developed and applied into the asymmetric Michael addition of pyrazolin-5-one to nitroalkenes. The catalyst system performed well with a low catalyst loading of 5 mol% under mild reaction conditions. A series of synthetically and pharmaceutically useful chiral pyrazolone derivatives was obtained in high yields (up to 95%) with good enantioselectivities (up to 88 % ee). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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