A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents
| Autor: | Ashlene Roddy, Jordan Atchison, James Davis, Aaron McConville |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Smart phone Transdermal patch 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Bluetooth Silver chloride chemistry.chemical_compound law Materials Chemistry Wireless Electrical and Electronic Engineering Instrumentation Transdermal Wax business.industry Metals and Alloys 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry visual_art Drug delivery visual_art.visual_art_medium 0210 nano-technology business Biomedical engineering |
| Zdroj: | Sensors and Actuators B: Chemical. 294:24-31 |
| ISSN: | 0925-4005 |
| Popis: | A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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