Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi
| Autor: | Sneh Lata Singh, Sudisht Kumar Sah, Vavilala A. Pratyusha, Sneha Sudha Komath |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Clinical Biochemistry Cell Saccharomyces cerevisiae Mutant ved/biology.organism_classification_rank.species Biochemistry Cell wall 03 medical and health sciences chemistry.chemical_compound Biosynthesis Genetics medicine Model organism Molecular Biology biology ved/biology Cell Biology biology.organism_classification Phenotype Yeast Cell biology 030104 developmental biology medicine.anatomical_structure chemistry lipids (amino acids peptides and proteins) |
| Zdroj: | IUBMB Life. 70:355-383 |
| ISSN: | 1521-6543 |
| DOI: | 10.1002/iub.1734 |
| Popis: | Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are present ubiquitously at the cell surface in all eukaryotes. They play a crucial role in the interaction of the cell with its external environment, allowing the cell to receive signals, respond to challenges, and mediate adhesion. In yeast and fungi, they also participate in the structural integrity of the cell wall and are often essential for survival. Roughly four decades after the discovery of the first GPI-APs, this review provides an overview of the insights gained from studies of the GPI biosynthetic pathway and the future challenges in the field. In particular, we focus on the biosynthetic pathway in Saccharomyces cerevisiae, which has for long been studied as a model organism. Where available, we also provide information about the GPI biosynthetic steps in other yeast/ fungi. Although the core structure of the GPI anchor is conserved across organisms, several variations are built into the biosynthetic pathway. The present Review specifically highlights these variations and their implications. There is growing evidence to suggest that several phenotypes are common to GPI deficiency and should be expected in GPI biosynthetic mutants. However, it appears that several phenotypes are unique to a specific step in the pathway and may even be species-specific. These could suggest the points at which the GPI biosynthetic pathway intersects with other important cellular pathways and could be points of regulation. They could be of particular significance in the study of pathogenic fungi and in identification of new and specific antifungal drugs/ drug targets. © 2018 IUBMB Life, 70(5):355-383, 2018. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text