In Silico Analysis of Curcuma longa Against PCAF Histon Asetiltransferase

Autor:	Artha Vinsentricia, Djarot Sasongko Hami Seno, Maria Bintang
Rok vydání:	2015
Předmět:	biology Materials Science (miscellaneous) In silico Active site biology.organism_classification Molecular biology In vitro analysis chemistry.chemical_compound Histone PCAF chemistry Biochemistry Docking (molecular) parasitic diseases biology.protein Curcumin Curcuma
Zdroj:	Current Biochemistry. 2:52-62
ISSN:	2355-7931 2355-7877
Popis:	Curcumin turmeric (C. longa) has been found capable of inhibiting p300/CBP associated factor (PCAF) histone asetyltransferase (HAT) as a cancer biomarker. However, the molecular mechanism of inhibition is unkown. This study is aimed to analyse the molecular inhibition mechanisms by in silico method. The analysis showed that curcumin’s Gibbs free energy (ΔG) was stable and capable of binding amino acid residues believed to be active site of PCAF HAT. Curcumin is predicted to be a PCAF HAT inhibitor, and further in vitro analysis is required.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d3edcd8ed1bdbfe2a6ae7fa6b577cbd6 https://doi.org/10.29244/cb.2.2.52-62 Zobrazit plný text záznamu