Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides

Autor:	Qian Zhao, Fengli Jin, Wei Han, Lifang Yao, Hongyan Du
Rok vydání:	2016
Předmět:	Formamide Primary (chemistry) 010405 organic chemistry Bioactive molecules Organic Chemistry 010402 general chemistry Cleavage (embryo) Highly selective 01 natural sciences 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Organic chemistry Formamides
Zdroj:	Synlett. 27:1854-1859
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0035-1561975
Popis:	Primary pyridylcarboxamides are prevalent parent structures in bioactive molecules and have the apparent advantages over N-protected derivatives as synthetic building blocks. However, no practical methods have been developed for direct synthesis of this compound class from unfunctionalized pyridines. We herein present a general, safe, concise, acid-free, and highly selective method for the C2-carba­moylation of pyridines with unprotected formamide and N-methyl formamide through the cleavage of two C–H bonds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d3d38f85adabdb9bd6410b166a7639e9 https://doi.org/10.1055/s-0035-1561975 Zobrazit plný text záznamu