| Autor: |
Masahisa Katsuno, Makoto Hattori, Keita Hiraga, Yuki Satake, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Akihiro Hori, Motoshi Kawashima, Hideaki Shimizu, Hiroshi Matsuda, Katsuhiko Kato, Yukihiko Washimi |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1999286/v1 |
| Popis: |
Individuals with prodromal symptoms of Lewy body disease (LBD), such as rapid eye movement sleep behavior disorder (RBD), often showed imaging defects similar to patients. We examined dopamine transporter (DaT) single-photon-emission computed tomography (SPECT) and metaiodobenzylguanidine (MIBG) scintigraphy in 69 high-risk subjects with ≥ 2 prodromal symptoms (dysautonomia, hyposmia, and RBD) and 32 low-risk subjects without prodromal symptoms, whom were identified through a questionnaire survey of health checkup examinees. The high-risk subjects had significantly worse scores on Stroop test, line orientation test, and the Odor Stick Identification Test for Japanese than the low-risk subjects. The prevalence of abnormalities on DaT-SPECT was higher in the high-risk group than in the low-risk group (24.6% vs. 6.3%, p = 0.030). A decreased uptake on DaT-SPECT was associated with motor impairment, and MIBG scintigraphy defects were associated with hyposmia. The simultaneous evaluation of DaT-SPECT and MIBG scintigraphy may capture a wide range of individuals with prodromal LBD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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