Autor:	Jiali Shen, Gary S. Stein, J. Y. Choi, Daniel Young, Jane B. Lian, Andre J. Van Wijnen, Soraya E. Gutierrez, S. Kaleem Zaidi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Shirwin M. Pockwinse, Kimberly Stacy Harrington
Rok vydání:	2003
Předmět:	Genetics Core Binding Factor alpha Subunits Biology Chromatin Cell biology Cell nucleus medicine.anatomical_structure Gene expression medicine Transcriptional regulation Nucleosome Gene Transcription factor
Zdroj:	Chromosome Research. 11:527-536
ISSN:	0967-3849
DOI:	10.1023/a:1024943214431
Popis:	There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d398a8679461e2d5e9f4b76202724590 https://doi.org/10.1023/a:1024943214431 Zobrazit plný text záznamu Full text from SpringerLink