Modulation of rabbit mitochondrial nuclease activity by S-adenosyl-L-methionine
| Autor: | D. E. Sobolev, B. F. Vanyushin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Nuclease
biology Molecular mass Substrate (chemistry) Rabbit (nuclear engineering) Methylation Mitochondrion Molecular biology General Biochemistry Genetics and Molecular Biology Endonuclease chemistry.chemical_compound Biochemistry chemistry biology.protein General Agricultural and Biological Sciences DNA General Environmental Science |
| Zdroj: | Moscow University Biological Sciences Bulletin. 68:15-18 |
| ISSN: | 1934-791X 0096-3925 |
| DOI: | 10.3103/s0096392513010070 |
| Popis: | Endonuclease activity with properties similar to those of the animal endonuclease G has been detected in extracts of rabbit liver mitochondria. This activity was detected in the fraction of proteins with molecular mass close to 30 kDa; it was stimulated by Mg2+ ions and inhibited by Zn2+ ions. In contrast to plant endonucleases WEN1 and WEN2, the rabbit endonuclease was not affected by methylation status of the substrate DNA, and S-adenosine-L-methionine inhibited it. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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