Reactivity and Safety of BioNTech/Pfizer® Vaccine Anti-SARS-CoV-2, in Health Personnel from the Mexican State of Guanajuato

Autor: Efraín Navarro -Olivos, Francisco J. Magos -Vázquez, María del Rosario Sánchez-Navarro, Daniel A. Díaz-Martínez, María de Jesús Gallardo-Luna, Nicolás Padilla- Raygoza
Rok vydání: 2022
Předmět:
Zdroj: Biomedical and Pharmacology Journal. 15:993-1003
ISSN: 2456-2610
0974-6242
DOI: 10.13005/bpj/2435
Popis: The Severe Acute Respiratory Syndrome Coronavirus 2, first detected in Wuhan, China, in 2019, had spread all over the world. It has caused the COVID-19 pandemic. Nowadays, there are effective and safe vaccines proven against this virus. The goal of this study was to verify it among health-care workers from the Institute of Public Health from Guanajuato State who received the BioNTech/Pfizer vaccine. For this purpose, we designed a quantitative cross-sectional study. The database was obtained from a previous strategy program by the Institute of Public Health from Guanajuato State called ENSERO-COVID. The available data consisted of two chemiluminescence measures of the IgG anti-Spike antibodies after one and six months of the BioNTech/Pfizer vaccine two doses application. The survey also included self-reported reactions to this vaccine. Frequency tables are presented for descriptive purposes. We performed the chi-square test, the z test for proportions, and the t-test for comparisons. Also, two linear regression models were fitted between the first and second chemiluminescence levels stratifying by prior infection by SARS-CoV-2. The database consisted of 177 records. Of them, 45 (25.4%) were positive for SARS-CoV-2 before vaccination. Only one person did not react to the two doses of vaccine application. Most of the self-reported reactions ceased in a short period -less than three days-. The differences observed, regarding chemiluminescence levels, between those with and without prior infection by SARS-CoV-2 were not statistically significant. More analyses are required to assess the long-term effects of the BioNTech/Pfizer ® vaccine.
Databáze: OpenAIRE
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