Phosphorylated Derivatives of Alkaloids and Nitrogen-containing Heterocycles — Cholinesterase Inhibitors

Autor:	D. N. Dalimov, A. S. Sadykov, Godovikov Nn
Rok vydání:	1983
Předmět:	biology Chemistry Stereochemistry Alkaloid Chemical structure chemistry.chemical_element General Chemistry Nitrogen Catalysis biology.protein Molecule Organic chemistry Phosphorylation Cholinesterase
Zdroj:	Russian Chemical Reviews. 52:918-930
ISSN:	1468-4837 0036-021X
DOI:	10.1070/rc1983v052n10abeh002895
Popis:	The review deals with the synthesis and anticholinesterase activities of phosphorylated derivatives of certain alkaloids and nitrogen-containing heterocycles. It is shown that the conformational properties of the alkaloid and nitrogen-containing heterocycle residues in the composition of the organophosphorus inhibitor (OPI) molecule play an important role in the inhibition of the catalytic activity of cholinesterases. The type of inhibition of cholinesterases also varies as a function of chemical structure. The bibliography includes 45 references.
Databáze:	OpenAIRE
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