Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells
| Autor: | Jie Huang, Xiang Li, Zhaohui Ren, Gaorong Han, Serena M. Best, Congkun Xie, Lun Qin, Peijian Yan, Xiujun Cai |
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| Rok vydání: | 2018 |
| Předmět: |
Small interfering RNA
Photothermal effect 02 engineering and technology Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Cell biology RNA interference Nanofiber Drug delivery Gene silencing General Materials Science Nanorod 0210 nano-technology |
| Zdroj: | Nanoscale. 10:13432-13442 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c8nr03802c |
| Popis: | Nanoparticles are now commonly used as non-viral gene vectors for RNA interference (RNAi) in cancer therapy but suffer from low targeting efficiency in situ. Meanwhile, localized drug delivery systems do not offer the effective capability for intracellular gene transportation. We describe here the design and synthesis of a localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers. This composite system offers the potential for a LED-induced mild photothermal effect which enhances the phagocytosis of Au NRs carrying siRNA and the subsequent release of siRNA in the cytoplasm. Both phenomena amplify the gene silencing effect and consequently offer the potential for a superior therapeutic outcome. |
| Databáze: | OpenAIRE |
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