Synthesis and Chiroptical Properties of Some N-(2-Chloro-7-cyclopropyl-4,7-dihydro-4-oxo-thieno[2,3-b]pyridine-5-carbonyl) L-α-Amino Esters

Autor:	Musa Z. Nazer, Salim S. Sabri, Marcela Geiger, Mustafa M. El-Abadelah, Wolfgang Voelter, Salim M. Khalil
Rok vydání:	1997
Předmět:	Circular dichroism chemistry.chemical_compound Amino esters chemistry Stereochemistry Pyridine General Chemistry
Zdroj:	Zeitschrift für Naturforschung B. 52:419-426
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-1997-0321
Popis:	A series of N-(2-chloro-7-cyclopropyl-4,7-dihydro-4-oxothieno[2,3-b]pyridine-5-carbonyl)-L-α-amino esters (5 ) have been prepared via the respective thieno[2,3-b]pyridinyl-5-carbonyl chloride (4). The CD spectra of the L-aliphatic (5a -d ) and L-aromatic (5e-g) a-amino acid derivatives display, in organic solvents, sign inversion of the measured Cotton effect (CE) bands. This chiroptical behaviour is probably associated with differences in conformational isomerism of either set. MS and NMR spectral data of the title compounds are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d24a7512af3eb3ffa02aeafacde86e4d https://doi.org/10.1515/znb-1997-0321 Zobrazit plný text záznamu