| Autor: |
Chelsea S Lutz, Rachel M Hartman, Deionna E Vigil, Amadea Britton, Amanda B Burrage, Angela P Campbell, Ryan M Close, Christine Desnoyers, Jennifer Dobson, Starla Garcia, Natasha Halasa, Elvira Honie, Miwako Kobayashi, Meredith McMorrow, Heba H Mostafa, Dennie Parker, Kyle Pohl, Mila M Prill, Jennifer Richards, Kristen C Roessler, Catherine G Sutcliffe, Kim Taylor, Amy Swango-Wilson, Puthiery Va, Jennifer R Verani, Rosalyn J Singleton, Laura L Hammitt |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Open Forum Infectious Diseases. 10 |
| ISSN: |
2328-8957 |
| Popis: |
Background Despite the disproportionate morbidity and mortality experienced by American Indian and Alaska Native (AI/AN) persons during the coronavirus disease 2019 (COVID-19) pandemic, few studies have reported vaccine effectiveness (VE) estimates among these communities. Methods We conducted a test-negative case-control analysis among AI/AN persons aged ≥12 years presenting for care from January 1, 2021, through November 30, 2021, to evaluate the effectiveness of mRNA COVID-19 vaccines against COVID-19-associated outpatient visits and hospitalizations. Cases and controls were patients with ≥1 symptom consistent with COVID-19-like illness; cases were defined as those test-positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and controls were defined as those test-negative for SARS-CoV-2. We used unconditional multivariable logistic regression to estimate VE, defined as 1 minus the adjusted odds ratio for vaccination among cases vs controls. Results The analysis included 207 cases and 267 test-negative controls. Forty-four percent of cases and 78% of controls received 2 doses of either BNT162b2 or mRNA-1273 vaccine. VE point estimates for 2 doses of mRNA vaccine were higher for hospitalized participants (94.6%; 95% CI, 88.0–97.6) than outpatient participants (86.5%; 95% CI, 63.0–95.0), but confidence intervals overlapped. Conclusions Among AI/AN persons, mRNA COVID-19 vaccines were highly effective in preventing COVID-associated outpatient visits and hospitalizations. Maintaining high vaccine coverage, including booster doses, will reduce the burden of disease in this population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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