Broccoli juice treated by high pressure: chemoprotective effects of sulforaphane and indole-3-carbinol
| Autor: | Jiří Totušek, Lucie Mandelová |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
0303 health sciences
030309 nutrition & dietetics Cruciferous vegetables food and beverages 04 agricultural and veterinary sciences Condensed Matter Physics 040401 food science 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Biochemistry chemistry Polyphenol High pressure Glucosinolate Micronucleus test Indole-3-carbinol Chemoprotective Food science Sulforaphane |
| Zdroj: | High Pressure Research. 27:151-156 |
| ISSN: | 1477-2299 0895-7959 |
| DOI: | 10.1080/08957950601082540 |
| Popis: | Numerous animal and epidemiological studies have demonstrated that consumption of cruciferous vegetables is inversely correlated with cancer incidence. Using the short-term mutagenicity test—in vivo micronucleus test, we investigated inhibition of mutagenicity of 2-amino-3-methyl-3H-imidazo-(4, 5-f)-quinoline (IQ) and N-nitroso-N-methylurea (MNU) by broccoli juice treated by high pressure (500 MPa), for a period of 10 min. This technique of treatment suppresses the growth of micro-organisms at simultaneous conservation of nutritionally important substances (vitamins, polyphenols, and glucosinolates). We also investigated anticlastogenic activity of sulforaphane (SFN) and indole-3-carbinol (I3C). These two substances are found in inactive form (glucosinolate) in cruciferous vegetables. Fourteen-day’s application of broccoli juice and three-day’s application of I3C and SFN led to statistically significant inhibition of mutagenicity IQ and MNU. It seems that, broccoli juice treated by high pressure and its m... |
| Databáze: | OpenAIRE |
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