Effects of an intraoperative infusion of 4% succinylated gelatine (Gelofusine®) and 6% hydroxyethyl starch (Voluven®) on blood volume
| Autor: | M. G. Dube, S. Dharmavaram, C. S. Wearn, Dileep N. Lobo, Sherif Awad |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry Bicarbonate Sodium medicine.medical_treatment Gelofusine chemistry.chemical_element Liter Blood volume Hydroxyethyl starch chemistry.chemical_compound Anesthesiology and Pain Medicine Endocrinology chemistry Internal medicine Anesthesia medicine Serum chloride business Saline medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 109:168-176 |
| ISSN: | 0007-0912 |
| Popis: | Background This study aims to study changes in blood volume after 1 litre infusions of Gelofusine® [4% succinylated gelatine in 0.7% saline, weight-average molecular weight (MWw) 30 kDa] and Voluven® (6% hydroxyethyl starch in 0.9% saline, MWw 130 kDa) in the presence of increased capillary permeability. Methods In this randomized double-blind study, adults undergoing laparoscopic cholecystectomy received 1 litre of Gelofusine® (n=12) or Voluven® (n=13) over 1 h at the induction of anaesthesia. No other fluids were given. Haematocrit, serum electrolytes, and osmolality were measured before infusion and hourly thereafter for 4 h. Changes in blood volume were calculated from changes in haematocrit. The urinary albumin:creatinine ratio (ACR) was measured before and after operation. Results Baseline parameters before the two infusions were similar (P>0.050). The urinary ACR increased significantly after operation after Gelofusine® (P=0.011) and Voluven® (P=0.002), indicating increased capillary permeability. Voluven® produced a greater increase in serum chloride concentration (P=0.028) and a larger decrease in strong ion difference (P=0.009) than Gelofusine®. There were no significant differences in changes in haematocrit (P=0.523) and blood volume (P=0.404) over the study period when the two infusions were compared, nor were there any differences in serum sodium, potassium, bicarbonate, and albumin concentrations (P>0.050). Urine output, sodium concentration, and osmolality were similar after the two infusions (P>0.050). Conclusions The blood volume-expanding effects of the two colloids were not significantly different, despite the increase in postoperative urinary ACR and the 100 kDa difference in MWw. |
| Databáze: | OpenAIRE |
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