Palladium-Catalyzed Cascade Synthesis of Novel Quinolone- Bis(indolyl)methane Hybrids as Promising α-Glucosidase Inhibitors
| Autor: | Xie Kaiqiang, Mingxing Zuo, Wen-Zhuang Qiu, Yuancui Liu, Lian Duan, Li-Ping Wang, Sheng Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Indole test
010405 organic chemistry medicine.drug_class Chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry Quinolone Ring (chemistry) 01 natural sciences Combinatorial chemistry Catalysis Methane 0104 chemical sciences chemistry.chemical_compound Cascade reaction Cascade medicine Palladium |
| Zdroj: | Synthesis. 52:1680-1686 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0039-1690871 |
| Popis: | An unexpected cascade reaction is developed for the construction of functionalized 3-bis(indol-3-yl)methylquinoline-2(1H)-ones. Three C–C bonds and one ring are created in one pot triggered by Pd-catalyzed C-3 alkenylation of indole with 2-acyl-N-acrylaniline derivatives. A series of complex and specific quinoline-2(1H)-ones were produced, most of them showed significant α-glucosidase inhibitory activities. |
| Databáze: | OpenAIRE |
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