Cooperative Ligand-Promoted P(III)-Directed Ruthenium-Catalyzed Remote Meta-C–H Alkylation of Tertiary Phosphines
| Autor: | Jia-Wei Li, Zheng-Xin Zhou, Liang-Neng Wang, Ming Li, Yue-Jin Liu, Ming-Hua Zeng |
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| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) 010405 organic chemistry Ligand Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Organic Chemistry chemistry.chemical_element Alkylation 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Ruthenium Suzuki reaction chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 23:2057-2062 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c00237 |
| Popis: | Herein, we disclose a ruthenium-catalyzed meta-selective C-H activation of phosphines by using intrinsic P(III) as a directing group. 2,2,6,6-Tetramethylheptane-3,5-dione acts as the ligand and exhibits an excellent performance in boosting the meta-alkylation. The protocol allows an efficient and straightforward synthesis of meta-alkylated tertiary phosphines. Several meta-alkylated phosphines were evaluated for Pd-catalyzed Suzuki coupling and found to be superior to commercially available ortho-substituted phosphines. The practicability of this methodology is further demonstrated by the synthesis of difunctionalized phosphines. |
| Databáze: | OpenAIRE |
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