Molecular and cellular toxicological profiling of DNA bis-intercalator, quinoxaline compounds: echinomycin as the versatile lead
| Autor: | Soo Ki Kim, Cheol-Su Kim, Xu Feng Qi, Yoon Sun Park, Woon Seob Shin, Chan Mug Ahn |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antitumor activity Cell signaling Health Toxicology and Mutagenesis Pharmacology toxicology Intercalation (chemistry) Public Health Environmental and Occupational Health Mitochondrion Echinomycin Toxicology Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Quinoxaline chemistry Biochemistry 030220 oncology & carcinogenesis General Pharmacology Toxicology and Pharmaceutics DNA |
| Zdroj: | Molecular & Cellular Toxicology. 14:9-18 |
| ISSN: | 2092-8467 1738-642X |
| DOI: | 10.1007/s13273-018-0002-8 |
| Popis: | Of quinoxaline compounds, echinomycin is classically known as an antitumor agent which binds to DNA via a mechanism of bis-intercalation. In addition to intercalation, quinoxaline compounds such as echinomycin, echinomycin derivatives or analogues might control anomalous cellular proliferation in eukaryotes via specifically triggering cellular signaling pathways in mitochondria, as well as under hypoxia. Further, since echinomycin was proven to be a specific inhibitor of HIF-1α, these novel mechanisms could be clinically applied in the development of therapeutics against cancer, infection, obesity, fibrosis, and autoimmune disease. Herein, this review focuses on the current toxicological profiles of echinomycin as well its potential applications in medicine. |
| Databáze: | OpenAIRE |
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