Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
| Autor: | Aisha Sabal, Sahar Mohamed Mostafa, Ahmed Abdelhaleem Mohamed, Rehab Ahmed, Yousry Esam-Eldin Abo-Amer, Sherief Abd-Elsalam, Mahmoud Salah Khalil, Rasha Refaie, Nabil Fathy Esmael Hasan, Waleed Elagawy |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Nonalcoholic fatty liver disease Internal Medicine medicine Outpatient clinic education Pharmacology education.field_of_study biology business.industry Fatty liver Helicobacter pylori medicine.disease biology.organism_classification digestive system diseases Steatohepatitis business |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:619-625 |
| ISSN: | 1178-7007 |
| Popis: | Background Non-alcoholic fatty liver disease (NAFLD) is a very common disease that affects 25-30% of the population in western countries. Many studies have observed the importance of H. pylori infection in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and liver fibrosis and cirrhosis. However, the evidence from different studies was controversial. The present study aimed to investigate the relationship between H. pylori infection and NAFLD in a developing country. Patients and methods This cross-sectional study included all the attending outpatient clinics at four Major University hospitals and two research and clinical institutes in a developing country in the period between June and October 2019. Patients were assessed for the diagnosis of H. pylori infection as detected by H. pylori antigen in stool; they were also assessed for the diagnosis of NAFLD by ultrasound, fibroscan, and CAP. Results The study was conducted on 646 patients; H. pylori infection was found to be present in 538 patients (83.3%). NAFLD (diagnosed by both U/S and Fibroscan with CAP), ALT, AST, hepatomegaly, hypertension, fasting blood sugar were significantly higher in H. pylori +ve group than H. pylori -ve group. After performing Linear regression of independent risk factors of NAFLD to prove or to refute the role of Helicobacter; H. pylori positivity, total cholesterol, degree of fatty liver by ultrasound, fasting blood sugar and diastolic blood pressure were independent risk factors for NAFLD. Conclusion Helicobacter pylori infection was independent risk factors for NAFLD and correlated with increased degree of steatosis. |
| Databáze: | OpenAIRE |
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