Expression level of miRNAS in patients with gestational diabetes
| Autor: | Filiz Çayan, Senay Balci, Didem Derici Yildirim, Lülüfer Tamer, Aysegul Gorur |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pregnancy business.industry Biochemistry (medical) Clinical Biochemistry 030209 endocrinology & metabolism medicine.disease Biochemistry Gestational diabetes 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine microRNA medicine Biomarker (medicine) In patient business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 45:825-831 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2019-0157 |
| Popis: | Background Gestational diabetes mellitus (GDM), which has been identified for the first time during pregnancy and is defined as glucose intolerance of varying degrees, is one of the prediabetes states that are at risk for developing type 2 diabetes. MicroRNAs (miRNAs) are associated with pregnancy complications and are even necessary for the regulation of pancreatic development and glucose-induced insulin secretion. This study aims to investigate miRNAs expressed in maternal plasma to detect the availability as a biomarker in the diagnosis of GDM. Methods In this study, 30 pregnant women with GDM diagnosed according to GDM American Diabetes Association criteria and 30 healthy pregnant women were included and miRNA expression levels were investigated. Circulating 39 miRNAs were analyzed by qRT-PCR using 96.96 Dynamic Array IFCs. Results The findings showed that the expression level of miR-7-5p significantly upregulated when compared with healthy pregnant women with gestational diabetes (fold change:2.3, p Conclusions There is controversy about what is the most appropriate test for GDM screening. Therefore, supported by further studies, miR-7-5p can be used for the diagnosis of GDM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|