PAI-1 Concentrations in First-degree Relatives of Patients with Non-insulin-dependent Diabetes: Metabolic and Genetic Associations

Autor:	Peter J. Grant, M. H. Stickland, Michael W. Mansfield
Rok vydání:	1997
Předmět:	medicine.medical_specialty Triglyceride Insulin medicine.medical_treatment Hematology Biology medicine.disease chemistry.chemical_compound Insulin resistance Endocrinology Blood pressure chemistry Diabetes mellitus Internal medicine Genotype medicine First-degree relatives Body mass index
Zdroj:	Thrombosis and Haemostasis. 77:357-361
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1655968
Popis:	SummaryAim: To identify whether levels of PAI-1 are elevated in relatives of NIDDM patients and the extent to which they relate to features of insulin resistance and to genotype at a common PAI-1 promoter polymorphism.Results: In 132 first-degree relatives of NIDDM patients and 151 controls PAI-1 activity was higher in relatives 14.4 U/ml than controls U/ml (p Conclusion: In relatives of NIDDM patients PAI-1 levels are elevated, presenting an additional mechanism for their increased cardiovascular risk.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf81fdc91214fac29f845e52e1ab0773 https://doi.org/10.1055/s-0038-1655968 Zobrazit plný text záznamu