Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids
| Autor: | Stefan Stolte, Nicole S. M. Vieira, Ana B. Pereiro, Marta Markiewicz, Luís Paulo N. Rebelo, João M. M. Araújo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
Renewable Energy Sustainability and the Environment Chemistry General Chemical Engineering Daphnia magna Context (language use) 02 engineering and technology General Chemistry Biodegradation 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences 0104 chemical sciences Aquatic toxicology Bioavailability Environmental chemistry Drug delivery Environmental Chemistry Sewage treatment Ecotoxicity 0210 nano-technology |
| Zdroj: | ACS Sustainable Chemistry & Engineering. 7:3733-3741 |
| ISSN: | 2168-0485 |
| Popis: | Several novel fluorinated ionic liquids (FILs), fully miscible with water and with excellent surfactant behavior, have been studied for pharmacological applications. The use of these novel FILs as drug delivery systems can improve the bioavailability, stability and efficacy of therapeutic proteins. An initial screening of toxicity in four different human cell lines indicated that some of the FILs possess low cytotoxicity. An environmental hazard assessment of these compounds, in the context of Green Pharmacy, is necessary before a pharmaceutical application takes place. In this work, ecotoxicity tests have been performed in aquatic species with different levels of biological organization (Vibrio fischeri, Daphnia magna and Lemna minor) to evaluate intrinsic hazard that these FILs might pose after being released to the aquatic environment from the human body or from industrial processes. Additionally, the biodegradability of these compounds has been evaluated using microorganisms from wastewater treatment ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|