Cyclic GMP-AMP synthase Regulates the Development of experimental autoimmune encephalomyelitis

Autor:	Monisha Mittal, Sha Tu, Hui Guo, Jian Zhang
Rok vydání:	2020
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 204:150.15-150.15
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.204.supp.150.15
Popis:	Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that activates type 1 IFN response via cGAS/cGAMP/STING-dependent pathway to defend against viral and bacterial infections. The role of c-GAS in adaptive immunity is completely unknown. In this study, we attempted to determine whether cGAS also regulates T cell responses using mice deficient for cGAS. We found that cGas−/− mice develop ameliorated experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, which correlates with defective Th1/Th17 responses. This reduced disease activity in cGas−/− mice is unlikely due to the expression cGAS in T cells because Rag1−/− recipients receiving Wild-type and cGas−/− CD4+ T cells develop a comparable degree of EAE. Therefore, our data suggest that cGAS expression in innate immune cells may indirectly regulate pathogenic Th1/Th17 responses during EAE induction.
Databáze:	OpenAIRE
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