Prolymphocytic leukemia: Treatment with combination chemotherapy to include doxorubicin
| Autor: | Joanne Rhoads, Barbara Detrick-Hooks, Donald S. Karcher, William M. Butler, H. Grant Taylor |
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| Rok vydání: | 1982 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Vincristine Pathology business.industry medicine.medical_treatment Standard treatment Splenectomy Combination chemotherapy CHOP medicine.disease Leukemia immune system diseases hemic and lymphatic diseases Internal medicine medicine Doxorubicin business Prolymphocytic leukemia medicine.drug |
| Zdroj: | Cancer. 49:1524-1529 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19820415)49:8<1524::aid-cncr2820490803>3.0.co;2-u |
| Popis: | Prolymphocytic leukemia (PL) is a clinically distinct leukemic disorder. Cytochemical and surface marker characteristics help to differentiate PL from other types of leukemia, including chronic lym-phocytic leukemia (CLL). In contrast to patients with CLL, those with PL frequently require early therapeutic intervention. Standard treatment regimens for CLL as well as splenectomy and splenic irradiation have not been effective in the treatment of PL. Combination chemotherapy with cyclo-phosphamide, Doxorubicin, vincristine, and prednisone (CHOP) has produced impressive clinical responses in patients with PL. The treatment of a patient with PL is discussed and the literature is reviewed. |
| Databáze: | OpenAIRE |
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