ILC3 Expansion in Acute Myeloid Leukemia
| Autor: | Thanh Thanh Trinh Dinh, Matthew R Lordo, Nikolas Shilo, Ekaterina Altynova, Parker Kronen, Megan Broughton, Victoria Sellers, Patrick Collins, Aharon G Freud, Bethany L Mundy-Bosse |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 208:171.07-171.07 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.208.supp.171.07 |
| Popis: | At homeostasis, type 3 innate lymphoid cells (ILC3s) are tissue-resident and have key roles in maintaining mucosal immunity. Recently, the expansion of ILC3s has been described in solid tumors; however, the mechanism driving this finding is not completely understood. In the setting of mouse and human acute myeloid leukemia (AML), we have observed an expansion of ILC3s. Using an AML murine model, we observed a 7-fold increase in ILC3s in the intestine (the normal ILC3 niche) of leukemic mice relative to controls and a 3-fold increase of ILC3s in the bone marrow (intestine: 0.208% +/− 0.04 AML vs 0.032% +/− 0.04 WT, n=5, p Supported by grant from NIH (1R01CA255860-01A1) |
| Databáze: | OpenAIRE |
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