Chronic Myeloid Leukaemia Presented with Extreme Isolated Thrombocytosis

Autor:	Md. Mahbubur Rahman, Tamanna Bahar, A K M Mynul Islam, Mohammad Ali, Zulfia Zinat Chowdhury, Salina Haque
Rok vydání:	2021
Předmět:	Thrombocytosis business.industry hemic and lymphatic diseases Immunology medicine Chronic myeloid leukaemia medicine.disease business
Zdroj:	Haematology Journal of Bangladesh. 5:73-76
ISSN:	2707-1405 2523-1219
DOI:	10.37545/haematoljbd202180
Popis:	CML presenting with isolated extreme thrombocytosis is rare. We reported a 47 years old man who presented with history of right sided lower abdominal pain, vomiting, significant lethargy and chest tightness. Patient was mildly anaemic and abdominal examination revealed no organomegaly. On investigation, he was found to have extreme thrombocytosis (2050x109/L) and mild leucocytosis (31.7 x109/L) with mild anaemia. In view of extreme thrombocytosis, he was investigated for myeloproliferative disease especially essential thrombocythemia. He was found to be positive for BCR-ABL by reverse transcription PCR (RT-PCR) and negative for JAK2, CALR, MPL mutations. Ultimately, he was diagnosed as a case of CML with an atypical presentation. He received imatinib 400 mg/day and achieve complete haematological response at 15 days.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cef6ba39dad51b73ec30a407abc9e662 https://doi.org/10.37545/haematoljbd202180 Zobrazit plný text záznamu