Design of Liposomes based Vaccine Adjuvant System

Autor:	Omkar A. Patil, Manojkumar M. Nitalikar, Girishchandra R. Mandake, Shital S. Shinde
Rok vydání:	2018
Předmět:	Liposome Materials science Phosphate buffered saline 030209 endocrinology & metabolism Microsphere 03 medical and health sciences 0302 clinical medicine Spray drying medicine 030212 general & internal medicine Telmisartan Solubility Dissolution Nuclear chemistry medicine.drug
Zdroj:	Asian Journal of Pharmacy and Technology. 8:261
ISSN:	2231-5713 2231-5705
DOI:	10.5958/2231-5713.2018.00040.5
Popis:	The purpose of this research work was to improve the solubility and therefore the rate of dissolution of Telmisartan using spray drying technique. Microspheres of Telmisartan were prepared by using various proportion of drug: PVP-K30 ratios (1: 1 to 1: 4). The prepared microspheres was subjected to in-vitro dissolution, FT-IR spectroscopy, XRD, and SEM studies. Present investigation describes preparation of microspheres by spray drying technique and the microspheres were found to be discrete, spherical with free flowing properties. The results indicated that formulation containing drug: PVP-K30 ratio of 1: 4, prepared by spray drying technique showed the cumulative release of 96.36% in phosphate buffer 7.5. Hence, it can be concluded that the microspheres prepared by spray drying technique have potential to enhance the solubility and dissolution rate of Telmisartan.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cef1ca4a3c7572434470923e8ffe2232 https://doi.org/10.5958/2231-5713.2018.00040.5 Zobrazit plný text záznamu