Abstract 13711: Coronary Artery Calcium, Ankle-brachial Index, High Sensitivity C-reactive Protein, and a Family History of Coronary Artery Disease as Predictors of Incident Cardiovascular Events at Different Stages of Hypertension: The Multi-ethnic Study of Atherosclerosis
| Autor: | Radha Kanneganti, Khurram Nasir, Zeina Dardari, Arthur S. Agatston, Karol E. Watson, Roger S. Blumenthal, Matthew J. Budoff, Erin D. Michos, Rajesh Tota-Maharaj, Ron Blankstein, Michael J. Blaha, Gregory L. Burke |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology business.industry C-reactive protein medicine.disease Coronary artery disease Coronary artery calcium medicine.anatomical_structure Physiology (medical) Internal medicine biology.protein Cardiology Medicine Ankle Family history Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 142 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circ.142.suppl_3.13711 |
| Popis: | Background: Coronary artery calcium (CAC), ankle-brachial index (ABI), high-sensitivity CRP (hsCRP), and family history (FHx) of coronary artery disease (CAD) are used as complementary aids in cardiac risk stratification. The 2017 ACC/AHA hypertension guideline’s new Stage I hypertension group has created uncertainty regarding intensity of blood pressure (BP) treatment in this group. We evaluated the comparative utility of CAC, ABI, hsCRP and FHx CAD as risk predictors of cardiovascular (CVD) events within different BP strata. Methods: The MESA cohort was followed for a median of 13 years with regards to incident coronary heart disease (CHD) and CVD events. BP was categorized per ACC/AHA guideline: normal- 300, CAC>75 t h %, ABI2 mg/L and FHx CAD, stratifying by BP groups after adjusting for demographics, CVD risk factors and use of BP and cholesterol medications. Results: Of 6268 persons, 539 incident CHD events and 572 incident CVD events were noted. CAC>300 and CAC>75 th % predicted an increased CHD event risk throughout all BP groups. ABI300 predicted a 2-fold increased CVD risk in all BP groups after adjustment. In the Stage I group, CAC>300, CAC>75 th % and ABI300 had a consistently higher C-statistic throughout all BP categories compared to other risk markers. Conclusion: CAC>300 was associated with increased CHD and CVD risk in all BP groups and demonstrated superior prognostic utility compared to other risk markers. CAC>300, CAC>75 th % and ABI |
| Databáze: | OpenAIRE |
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