A novel solid support for the synthesis of 3 ′ -aminoalkylated oligonucleotides

Autor:	Rubina Giare, Nicole Zien, Matthias Paul, Michael Leuck, Andreas Wolter
Rok vydání:	2004
Předmět:	chemistry.chemical_compound Controlled pore glass CpG site Chemistry Oligonucleotide Organic Chemistry Drug Discovery Organic chemistry Hydroxymethyl Protecting group Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 45:317-320
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2003.10.166
Popis:	A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3′-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3′-amino groups from the support is complete within 2 h at 55 °C in concentrated ammonia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd3ef749e44538fe405f8987f4a5ebd8 https://doi.org/10.1016/j.tetlet.2003.10.166 Zobrazit plný text záznamu Full Text from ScienceDirect