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The role of opioid neuropeptides and immunization of animals by inoculating conjugates was studied in the comparative rows of mammals (hedgehogs, cats, and monkeys) to consider the possibility of compensating for neurotic disorders of higher nervous activity (HNA). It was found that small doses of β-endorphin (15–25 μg/kg) and met-enkephalin produce a short-term facilitating effect on HNA. The administration of large doses (50–80 μg/kg) aggravates neurosis. Immunization by using the β-endorphin conjugate leads to the normalization of impaired brain functions by all HNA indices. Normalization of brain functions is accompanied by the formation of antibodies in blood plasma. The compensatory effects of immunization inoculating the β-endorphin conjugate are most manifest and stable (three to four months) in monkeys. The question of the interaction between the nervous and immune systems is discussed in the article. |
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