Canine mammary carcinoma: current therapeutic targets and future perspectives – a review

Autor: Muhammad Luqman Nordin, Ahmad Khusairi Azemi, Noraznawati Ismail, Abu Hassan Nordin, Walid Nabgan, Nur Amalina Noralidin, Rumaizi Shaari, Nur Zul Izzati Mohd Rajdi, Mohd Farhan Hanif Reduan, Hawa Nordin Siti, Aida Hanum Ghulam Rasool, Nik Nor Izah Nik Ibrahim
Rok vydání: 2023
Zdroj: Annals of Animal Science.
ISSN: 2300-8733
Popis: Canine mammary carcinoma (CMC) is the most common neoplasm in bitches, and it shares many biological similarities with breast cancer in humans. Drug resistance, high epigenetic mutations, and relapse rates are among the challenges which eventually urge the need for a veterinary oncologist to discover new therapeutic approaches that are more effective and safer. Therefore, in this review, we also cover the current therapeutic strategies from human medicine for the future perspectives of tumor immunotherapy in veterinary medicine. These strategies have great potential to be employed as therapeutic or prophylactic options due to their ability to modulate a specific and potent immune response against CMC. As we acquire a better understanding of canine tumor immunology, we can move towards a brighter prognosis. Additionally, we report on the recent successful studies in breast cancer that may benefit canines as well.
Databáze: OpenAIRE