Synthesis of Isotopically Labeled Anti-HIV Nucleoside Islatravir through a One-Pot Biocatalytic Cascade Reaction

Autor:	Kevin M. Maloney, Aaron M. Whittaker, David J. Waterhouse, Neil A. Strotman, Mark A. Huffman, Sumei Ren, Christopher C. Nawrat, Hao Yang
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Anti hiv Organic Chemistry Human immunodeficiency virus (HIV) 010402 general chemistry medicine.disease_cause 01 natural sciences Combinatorial chemistry 0104 chemical sciences Cascade reaction Biocatalysis medicine Physical and Theoretical Chemistry Nucleoside
Zdroj:	Organic Process Research & Development. 25:516-521
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00476
Popis:	We report the synthesis of the carbon-14-labeled unnatural nucleoside islatravir, an investigational HIV drug, through a one-pot biocatalytic cascade starting from acetaldehyde-2-14C. Combining enz...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cc0fa76d86e44cb8a5e9430984cb30e7 https://doi.org/10.1021/acs.oprd.0c00476 Zobrazit plný text záznamu