Know Your Model: A brief history of making mutant mouse genetic models

Autor:	Cynthia L. Smith, Michelle N. Perry, Susan M. Bello
Rok vydání:	2021
Předmět:	General Veterinary Mutant Genetic model Animal Science and Zoology Research questions Computational biology Biology Allele Genome
Zdroj:	Lab Animal. 50:263-266
ISSN:	1548-4475 0093-7355
Popis:	For over a century, researchers have used mice as models and adapted many new methods to create novel mutations in them. In the past 100+ years, we have gone from breeding strains for selected traits to inducing random mutations throughout the genome to creating designer alleles with multiple functions. Each method offers opportunities and challenges for researchers as they try to address specific research questions with mouse models.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cb2a3de1473d64ce7b26b8e5468586c5 https://doi.org/10.1038/s41684-021-00853-5 Zobrazit plný text záznamu Full text from SpringerLink