Antimicrobial Resistance Pattern among Community-Acquired Gram-Positive and Gram-Negative Bacterial Bloodstream Isolates in India
| Autor: | Vidya Nerurkar, Mamta Kumari, Bibhu Ranjan Das, a Dey, Sun, Uma Ramesh, Viral Vadwai |
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| Rok vydání: | 2015 |
| Předmět: |
Carbapenem
biology business.industry Broth microdilution General Medicine biochemical phenomena metabolism and nutrition Acinetobacter biology.organism_classification Antimicrobial medicine.disease_cause Acinetobacter baumannii Microbiology chemistry.chemical_compound Antibiotic resistance chemistry Staphylococcus aureus Linezolid Medicine business medicine.drug |
| Zdroj: | Annals of Clinical and Laboratory Research. 3 |
| ISSN: | 2386-5180 |
| DOI: | 10.21767/2386-5180.100010 |
| Popis: | Aim: To perform a retrospective analysis to assess the antimicrobial resistance pattern of gram positive- and negative- organisms involved in causing bloodstream infections. Antimicrobial susceptibility was performed using broth microdilution methodologies and results were interpreted using Clinical and Laboratory Standards Institute guidelines. Results: This study included 1825 gram-positive and 2986 gram-negative isolates. Twenty-nine percent (108/372) of the Staphylococcus aureus isolates were methicillin resistant with high rate of susceptibility for glycopeptides (>95%). Among the Enterococcus species, 12.1% (18/154) isolates were vancomycin resistant; also conferring resistance to linezolid (3.3%, 5/154). Most gram negative organisms recorded high level resistance to cephalosporins (>70%), fluoroquinolones (>50%) and β-lactum agents (>65%). Extended-spectrum β-lactamases (ESBLs) were reported among 52.8% (346/655) of Escherichia coli; and of these, 5.3% (18/346) isolates conferred carbapenem resistance. Similarly, reduced carbapenem susceptibility was reported against Acinetobacter spp. (62-83%; [Acinetobacter baumannii, ~85%]) and Pseudomonas spp. (62%; [Pseudomonas aeroginosa |
| Databáze: | OpenAIRE |
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