COMPARISON OF PREGABALIN AND NORTRIPTYLINE ON SLEEP, QUALITY OF LIFE IN POSTHERPETIC NEURALGIA: A PROSPECTIVE, RANDOMISED, OPEN-LABEL, PARALLEL STUDY

Autor:	Kanika Khajuria, Seema Gupta, Dev Raj Dogra, Vijay Khajuria, Dinesh Kumar
Rok vydání:	2021
Předmět:	Pharmacology medicine.medical_specialty Sleep quality Postherpetic neuralgia business.industry Pregabalin Pharmaceutical Science Parallel study medicine.disease Quality of life Internal medicine medicine Outpatient clinic Nortriptyline Open label business medicine.drug
Zdroj:	International Journal of Pharmacy and Pharmaceutical Sciences. :27-30
ISSN:	0975-1491 2656-0097
DOI:	10.22159/ijpps.2021v13i6.41244
Popis:	Objective: Aim of the present study was to compare the effects of pregabalin and nortriptyline on sleep and quality of life in patients of postherpetic neuralgia (PHN). Methods: The present study was conducted in 48 patients of PHN attending the outpatient department (OPD) of Dermatology, Government Medical College Jammu. Based on inclusion/exclusion criteria patients were randomized into two treatment groups. One group received pregabalin 150 mg/day and the other group was treated with nortriptyline 25 mg/day. The patients were followed up to eight weeks and assessed for Sleep (Medical Outcomes Study sleep scale) and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC) score and Patient Global Impression of Change (PGIC) score were used to evaluate overall clinical improvement. Results: Both drugs significantly improved all parameters studied (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ca02c145bdec7b1abac3dae948df53c0 https://doi.org/10.22159/ijpps.2021v13i6.41244 Zobrazit plný text záznamu