Disseminated Intravascular Coagulation in Prostatic Carcinoma Reversed by Ketoconazole
| Autor: | Herbert Lepor, William R. Bell, Marc R. Litt |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Disseminated intravascular coagulation
Chemotherapy medicine.medical_specialty Pathology business.industry medicine.medical_treatment Urology General Medicine medicine.disease Sepsis medicine.anatomical_structure Prostate hemic and lymphatic diseases Coagulopathy Carcinoma Medicine Ketoconazole business Complication circulatory and respiratory physiology medicine.drug |
| Zdroj: | JAMA: The Journal of the American Medical Association. 258:1361 |
| ISSN: | 0098-7484 |
| Popis: | DISSEMINATED intravascular coagulation (DIC) is a well-recognized complication of malignant neoplasms. Between 13% and 25% of the patients with chronic DIC have underlying prostatic carcinoma. 1,2 The mechanism of DIC in these patients appears to be related to release of thromboplastins from prostatic tissue. 3 The treatment of DIC involves prompt identification, with control or eradication of the underlying disease process. Correction of circulatory volume, hemostatic elements, and possible sepsis is mandatory. The use of heparin sodium (Panheparin), e-aminocaproic acid, and exogenous estrogens in DIC related to prostatic carcinoma remains controversial. 4 The following report describes the use of ketoconazole in the treatment and reversal of DIC associated with prostatic carcinoma. Report of a Case An 82-year-old man with metastatic prostatic cancer was transferred to The Johns Hopkins Hospital, Baltimore, for evaluation of a coagulopathy and hematuria. Two years previously, the patient developed symptoms of urinary obstruction and underwent a |
| Databáze: | OpenAIRE |
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