Peanut Component Ara h 1 and 2 Sensitization in Patients with Food Allergy in Kuwait

Autor:	Tito Rodriguez-Bouza, Mona Al-Ahmad, Edin Jusufovic, Nermina Arifhodzic
Rok vydání:	2021
Předmět:	biology business.industry Oral food challenge Immunology Peanut allergy General Medicine medicine.disease Immunoglobulin E medicine.anatomical_structure Older patients Food allergy medicine biology.protein Immunology and Allergy In patient Antibody business Sensitization
Zdroj:	International Archives of Allergy and Immunology. 183:315-321
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000519297
Popis:	Introduction: There is limited knowledge on the sensitization patterns to peanut proteins and food allergy in the Middle East. The objective of this study is to analyze the relationship between sensitization patterns to peanut proteins and clinical symptoms in a group of patients with physician-diagnosed peanut allergy (PA) in Kuwait. Methods: PA patients were evaluated by the skin prick test (SPT), serum total IgE, peanut-specific IgE (sIgE), and sIgE against Ara h 1–3, 8, and 9, and clinical data were collected. Results: Sixty-nine patients were included. A positive correlation between peanut SPT and sIgE was detected for all 3 storage proteins (Ara h 1–3) in patients p = 0.0046 and p = 0.0378). The levels of Ara h 1 and 2 were also significantly higher in patients with systemic reactions compared to those with a local reaction, with those differences being especially relevant for Ara h 2 (15.9 vs. 0.4) (p = 0.0005). Conclusions: The pattern of sensitization to peanut proteins in the Middle East is similar to that of the Western world. Measurement of sIgE antibodies to Ara h 1, 2, and 3 is useful in the diagnosis of PA and in the investigation of reactions to raw and roasted peanuts.
Databáze:	OpenAIRE
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