Synthesis, Structure, DFT, and Biological Activity of Metal Complexes of Norfloxacin and Metformin Mixed Ligand

Autor:	Wael A. Zordok, M. El-Telbany, L. M. Abbass, Walaa H. El-Shwiniy, Sadeek A. Sadeek
Rok vydání:	2021
Předmět:	Metal ions in aqueous solution Imine General Chemistry Medicinal chemistry Magnetic susceptibility Metal chemistry.chemical_compound chemistry Octahedron visual_art Proton NMR visual_art.visual_art_medium Chelation Carboxylate
Zdroj:	Russian Journal of General Chemistry. 91:1774-1782
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221090243
Popis:	A new series of mixed ligand metal complexes has been synthesized by the reaction of Co(II), Ni(II), Cu(II), Zr(IV), Pd(II), and Cd(II) with norfloxacin (NOR) and metformin hydrochloride (MF) in 1 : 1 : 1 molar ratio. The complexes have been characterized by FT-IR, UV-Vis, and 1H NMR spectra, TG/DTG and elemental analysis, molar conductance, and magnetic susceptibility data. According to FT-IR, NOR chelates with metal ions as a bidentate ligand via one oxygen of the carboxylate group and pyridone oxygen, and MF chelates with metal ions via two imine groups. Complexes have been identified as electrolytes. Electronic and magnetic data have indicated the octahedral structure for all complexes except square planar Pd(II) complex. Antibacterial and antifungal activities of the compounds have been tested against several species, and have indicated higher inhibition against micro-organisms for the metal complexes than the mixed ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c98525ff8ed77017084420004039309e https://doi.org/10.1134/s1070363221090243 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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