Insights on biomarkers from Chinese hamster ovary ‘omics’ studies

Autor:	Sarantos Kyriakopoulos, Cleo Kontoravdi
Rok vydání:	2014
Předmět:	Transcriptome Metabolomics High productivity Chinese hamster ovary cell Computational biology Biology Bioinformatics Omics
Zdroj:	Pharmaceutical Bioprocessing. 2:389-401
ISSN:	2048-9153 2048-9145
Popis:	As efforts for selecting high-producing cells during cell line development are moving toward the use of high-throughput, automated methods, there is considerable promise for identifying suitable markers arising from transcriptomic, proteomic and metabolomic studies. Herein we discuss the opportunities presented from recent characterization studies of high producers as well as comparisons with non- and lower-producing clones. We further put forward unique characteristics of cell lines with high productivity, which can be used for cell line screening and genetic engineering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c95cd963461c9fb7c0285457f33dc65e https://doi.org/10.4155/pbp.14.45 Zobrazit plný text záznamu