HIV Type 1 Abrogates TAP-Mediated Transport of Antigenic Peptides Presented by MHC Class I

Autor:	Thomas Kerkau, Olaf Kutsch, T. Hünig, T. Vey, Anneliese Schimpl
Rok vydání:	2002
Předmět:	biology Antigen processing Immunology Antigen presentation chemical and pharmacologic phenomena Transporter associated with antigen processing MHC restriction Virology Infectious Diseases Immune system MHC class I biology.protein Cytotoxic T cell Viral Interference
Zdroj:	AIDS Research and Human Retroviruses. 18:1319-1325
ISSN:	1931-8405 0889-2229
DOI:	10.1089/088922202320886361
Popis:	Downregulation of MHC class I expression following human immunodeficiency virus 1 (HIV-1) infection is thought to play an important role in viral escape from immune recognition by cytotoxic T-lymphocytes (CTLs). Since exogenous addition of HIV-1-derived peptides restores susceptibility of HIV-1-infected cells to CTL-mediated lysis, we tested whether endogenous peptide loading is impaired in these cells. Our results show that in HIV-1-infected cells the ability of the transporter associated with antigen presentation (TAP) to translocate antigenic peptides from the cytosol to the lumen of the ER for presentation on MHC class I molecules is abolished. These data suggest that interference with the supply of antigenic peptides to the MHC class I pathway provides an additional mechanism by which HIV-1 evades the CTL-mediated immune response.
Databáze:	OpenAIRE
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