Characterization of grlA , grlB , gyrA , and gyrB Mutations in 116 Unrelated Isolates of Staphylococcus aureus and Effects of Mutations on Ciprofloxacin MIC
| Autor: | Franz-Josef Schmitz, Ulrich Hadding, B. Hofmann, Birgit Hansen, Marc Lückefahr, Karl Köhrer, Hans-Peter Heinz, Ad C. Fluit, Jan Verhoef, Sibylle Scheuring, Mark E. Jones |
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| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
Genetics Mutation Drug resistance biochemical phenomena metabolism and nutrition Biology medicine.disease_cause DNA gyrase Microbiology Ciprofloxacin Minimum inhibitory concentration Infectious Diseases Staphylococcus aureus medicine Pharmacology (medical) Gene Antibacterial agent medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 42:1249-1252 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | One hundred sixteen unrelated clinical isolates of Staphylococcus aureus (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations in the grlA , grlB , gyrA , and gyrB gene loci. Two mutations within grlA (located at codons 80 and 84) and two mutations within gyrA (located at codons 84 and 88) were clearly associated with ciprofloxacin resistance, although other mutations detected within the four genes studied may also contribute to decreased susceptibility. |
| Databáze: | OpenAIRE |
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