Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: synthesis and implications for treatment of myocardial ischemia

Autor:	Tre R Welch, Jeffrey E. Thatcher, Robert C. Eberhart, J. Michael DiMaio, Zoltan A. Schelly
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Poly lactide co glycolide Myocardial ischemia History and Philosophy of Science chemistry General Neuroscience Biophysics Nanotechnology Peptide Thymosin β4 General Biochemistry Genetics and Molecular Biology Microsphere
Zdroj:	Annals of the New York Academy of Sciences. 1270:112-119
ISSN:	0077-8923
DOI:	10.1111/j.1749-6632.2012.06681.x
Popis:	A sustained release formulation for the therapeutic peptide thymosin β4 (Tβ4) that can be localized to the heart and reduce the concentration and frequency of dose is being explored as a means to improve its delivery in humans. This review contains concepts involved in the delivery of peptides to the heart and the synthesis of polymer microspheres for the sustained release of peptides, including Tβ4. Initial results of poly(lactic-co-glycolic acid) microspheres synthesized with specific tolerances for intramyocardial injection that demonstrate the encapsulation and release of Tβ4 from double-emulsion microspheres are also presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7ba60447edc5ae6692b7ace077e6af0 https://doi.org/10.1111/j.1749-6632.2012.06681.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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