Attractor Analysis of the Asynchronous Boolean Model of the Klotho Gene Regulatory Network
| Autor: | Malvina Marku, Klotilda Nikaj, Inva Koçiaj, Margarita Ifti |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chemical process Theoretical computer science Boolean model Gene regulatory network Fixed point Topology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Asynchronous communication 030220 oncology & carcinogenesis Attractor State space Klotho Mathematics |
| Zdroj: | Complex Networks VIII ISBN: 9783319542409 |
| DOI: | 10.1007/978-3-319-54241-6_22 |
| Popis: | When analyzing the state space attractors and their basin of attraction, two main methods have been used: the synchronous update method and the asynchronous update method. Although its simplicity, the synchronous update fails to consider various time scales of the chemical processes between the components within the network. To overcome this limitations, several asynchronous methods have been developed. In this work, we use two different asynchronous methods to study the dynamics of the wild-type and perturbed Klotho gene and carry out comparative results with previously published results. Prior evidence shows that the system develops oscillations and a fixed point. The numerical results of the both asynchronous methods show that, the system’s oscillations disappear and the system undergo in only one time-invariant fixed point, leading to an extended attractor. This work aims to highlight different behavior of the Klotho gene under various internal and external perturbations. |
| Databáze: | OpenAIRE |
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